UK’s first MS patient receives CAR T-cell therapy in landmark trial

UK's First MS Patient Receives CAR T-Cell Therapy

A UK woman with Multiple Sclerosis (MS) has become the first in the country to receive CAR T-cell therapy as part of a trial at University College London Hospitals NHS Foundation Trust (UCLH).

The innovative treatment, initially developed for cancer, reprograms a patient's own immune cells to target the B-cells driving MS, offering hope that a single infusion may one day stop relapses and irreversible nerve damage.

Multiple sclerosis (MS) affects the central nervous system, including the brain and spinal cord, causing symptoms such as blurred vision and problems with movement, memory, and thinking due to damaged myelin that protects nerves.

The treatment offers hope that a single infusion may one day stop relapses and irreversible nerve damage.

Author's summary: CAR T-cell therapy breaks new ground in treating MS.

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Open Access Government Open Access Government — 2025-10-28

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